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Thirteen exceptional mutations that explain…

Feb 7, 2022

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The previously mentioned Omicron mutation interaction study by Martin DP et al. , deserves further investigation. This team focused its attention on 13 of the 30 mutations present in the gene for the Spike protein of Omicron, mutations hitherto exceptionally encountered in other sarbecoviruses, even in the numerous ones present in bats.

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RELEVANCE OF THE ANTI-COVID VACCINE STRATEGY 19

Jan 20, 2022

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aIn March 2020, the stunned world is feeling the effects of the first wave of Covid 19: overwhelmed hospitals, and worrying lethality. It will be the first confinement, and state of health emergency, with its share of instructions and restrictions. December 2020 sees the dawning of hope for a solution, with the announcement of... 

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EMA/FDA update on the safety of Comirnaty® and the analysis of adverse events for Covid-19 vaccines

Mar 15, 2021

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The EMA recently issued their first update on Comirnaty® on January 28th 2021. The investigation of reports of anaphylactic reactions and the risk of death following the vaccination in frail elderly individuals by professionals did not suggest a safety concern.

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Gains of Functions

Feb 7, 2022

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Any experiment seeking to increase one of the following three viral properties, is considered a gain-of-function study:

  • Transmissibility

  • Pathogenicity

  • Resistance to immunity and/or treatments

This research mainly concerns airborne viruses.

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SARS-CoV-2 : THE VARIANTS TRIAL ( updated 20 April 2021)

Feb 1, 2021

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« British », « South African » or « Brazilian », who are they, and what are their capabilities?

The emergence of new SARS-CoV-2 variants coincided with an outbreak of infections in Britain, South Africa and Brazil. Now these variants are spreading around the world. What are they, and what are their dangers? 

New Update :20 April 2021 

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Pregnancy/fertility data in the clinical trials of the mRNA vaccines

Feb 3, 2021

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Questions have been recently raised related to the fertility of women receiving the Covid-19 Vaccine.

We present what is known to date on the fertility/pregnancy outcomes of women receiving the Covid19 vaccines in the two Phase 2/3 trials today approved by several regulatory agencies (e.g EMA, FDA) to protect patients from Covid19:

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Kawasaki disease and Covid-19 - Update January 2022

Jan 27, 2022

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The SARS-Cov-2 (Covid-19) virus officially appeared in China in December 2019. Although a member of the known family of coronaviruses, it is a newcomer whose virological, epidemiological, clinical and prognostic characteristics are gradually apprehended. At each stage, we have witnessed a succession of news published too quickly...

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Is mRNA vaccine, a vaccine or gene therapy ?

Jan 28, 2021

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Vaccination with mRNA has nothing to do with gene therapy

Gene therapy introduces genetic material in order to correct or replace a defective gene, as a treatment of genetic disease or a cancer.

Whereas, mRNA vaccine enables cells to temporarily express the Spike protein at their surface. 

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Male and female reproductive inclusion criteria in phase 3 studies

Feb 2, 2021

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 In the BioNtech/Pfizer protocol C4591001 for the Phase 3 study of Comirnaty (below), the Appendix 4 describes strict male and female reproductive inclusion criteria.

Are all these precautions standard precautions in all vaccine trials?

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